Asish Chaudhuri, PhD

I am Asish Chaudhuri, Ph.D; a well-trained, experienced protein biochemist. Currently, I work at the University of the Incarnate Word Osteopathic Medicine (UIWSOM) as SIGs Facilitator. Before I joined to UIWSOM, I worked as faculty members and Senior Staff Scientists at different academic Institutions including Barshop Institution for Aging at San Antonio, Texas; UT Southwestern Medical Center at Dallas, Texas, and at the Buck Institute for Aging, California.

Last 30 years, I worked mainly on two important aspects; first, teaching /guiding /mentoring graduate students and post-doctoral fellows to understand drug protein interaction and the biology of aging and age-related diseases, and secondly, technology development to address important biological questions. Till now, I have developed several technologies and trained more than 35 students in my whole career who were graduate students, post-doctoral fellows, junior faculties, and research associates. In parallel, I worked on several research projects to understand the role of proteins in modulating physiological functions; for example, drug-protein interaction to aging, comparative biology linked to longevity and pathophysiological conditions like aging brain, ALS, Alzheimer’s and diabetes. I received 13 grants as Principal Investigator and as co-investigators. I have published 49 peer-reviewed papers in journals including Nature Communication, PNAS, Aging Cell, FASEB J (Cover page story).,

In 2017, we discovered that FDA approved anti-hypertension drug hydralazine possesses anti-aging property and induces neurogenesis. I was the main instrumental for this project. We received a patent (WO2017160864A8) on these discoveries. Last four and half years, we found consistently that the principal component of ketone bodies, namely BHB (Beta hydroxybutyrate) extends lifespan and restore brain function of aging and Alzheimer’s mouse models. In future, my plan is to develop a research program at the UIWSOM addressing important biological questions of diseases linked to osteopathic medicine.